Osmosis Jones (2001)

Osmosis Jones is a 2001 American live-action/animated buddy cop action comedy film directed by the Farrelly brothers and written by Marc Hyman. The film stars the voices of Chris Rock, Laurence Fishburne, David Hyde Pierce, Brandy Norwood and William Shatner, alongside Molly Shannon, Chris Elliott and Bill Murray in live-action roles. It combines live-action sequences directed by the Farrelly Brothers and animated ones directed by Piet Kroon and Tom Sito. It follows the titular protagonist, an anthropomorphic white blood cell police officer, as he teams up with a cold pill to protect his unhealthy human host from a deadly virus he unintentionally contracted.

Filming took place in Plymouth, Massachusetts from April to June 2000. Although originally expected to be released in November 2000 it premiered on August 7, 2001, and was theatrically released three days later on August 10 by Warner Bros. Pictures. It received mixed reviews from critics, who praised the worldbuilding, animation, story and voice performances, but also criticized the inconsistent tone of the live-action portions and overuse of gross-out humor. The film was also a commercial failure, grossing $14 million worldwide against a $70 million budget. Despite the poor financial response, the film garnered success on home video, followed by an animated television series Ozzy & Drix, which aired on Kids' WB for two seasons and twenty-six episodes from 2002 until 2004.